Category Archives: Health
Kris Jenner Opens a New Window. made a grand entrance Opens a New Window. on the red carpet at New York City’s prestigious annual Met Gala on Monday, May 6. But it was not Jenner’s attire that people were so startled by — it was her brand new face!
RadarOnline.com spoke exclusively to three plastic surgeons to find out what exactly Jenner appeared to have done to turn back time.
Piers Morgan experienced the feeling of labour pains through a simulation machine on Good Morning Britain today.
The presenter, 54. who has previously admitted that he suffered during the birth of his daughter, was put to the test as he was attached to a TENS machine.
Finnish researchers at the University of Eastern Finland and the University of Oulu have discovered of a new type of gene mutation that reduces fear and anxiety, and increases social interaction. The researchers employed gene manipulation technology to remove the P4h-tm gene from the mouse genome and found an unexpected change in mouse behaviour. P4h-tm knockout mice showed striking courage and a lack of learned helplessness compared to congenic wild-type mice with a functional P4h-tm gene. The results were published in Neuropharmacology.
The researches assessed the mice with a large behavioural test battery that included a novel type of test for the panic reaction. The mice were placed in an air-tight box that was first filled up with regular room air, then with 10% carbon dioxide. An elevated concentration of carbon dioxide induces an innate freezing reaction that is thought to resemble the feeling of suffocation in patients suffering from panic attacks. P4h-tm knockout mice displayed substantially less freezing than control mice in response to carbon dioxide exposure. In tests for social interaction, P4h-tm knockout mice made clearly more contact with another mouse than the controls. In addition, behavioural tests routinely used for screening antianxiety and antidepressant drugs revealed reduced fear, anxiety and learned helplessness in P4h-tm knockout mice. Further, the study found a connection between brain anatomy and the behavioural phenotype: the expression of the P4h-tm gene was especially high in the amygdala that plays a key role in controlling emotional reactions, including fear and anxiety.
The P4h-tm gene accounts for the transcription of the P4H-TM protein. This protein belongs to the family of prolyl-4-hydroxylases that play a pivotal role in the cellular adaptation to a sudden lack of oxygen. However, the P4H-TM protein differs from other prolyl-4-hydroxylases in both its structure and unusual location (endoplasmic reticulum). The physiological role of the P4H-TM protein remains elusive despite years of intensive research, but it is assumed to have other effects on cellular biology besides adaptation to varying oxygen levels. The researches also tested the inactivation of three other known prolyl-4-hydroxylases in separate mouse lines. These mice did not show abnormal behaviour in the above-mentioned tests.
“Our findings are really interesting, but based on a recent international study led by the University of University, we know that the deficiency of the P4H-TM gene results in severe developmental defects in humans,” Professor Heikki Tanila from the University of Eastern Finland notes and continues: “However, in light of present knowledge, we cannot tell whether these harmful effects arise from embryonal development or whether they would also appear if the function of the P4H-TM protein was inhibited in the adult age.”
“We could best find an answer to this question by using conditional gene inactivation in which the gene could be turned off at any desired age,” Dr Henri Leinonen, the first author of the article, concludes.
“In an ideal experiment, P4h-tm would be turned off only in the amygdala of an adult mouse,” Dr Leinonen adds.
Although the striking effect of P4h-tm gene knockout on the emotional reactions of mice is still far away from therapeutic application, it can before long lead to the discovery of neurochemical mechanisms that regulate emotions, and can help to develop novel antianxiety and antidepressant drugs. Anxiety disorders and depression are a huge global problem. According to the World Health Organization (WHO), almost 300 million individuals worldwide suffer from anxiety disorders, and over 300 million suffer from depression.
For further information, please contact:
Professor Heikki Tanila, A. I. Virtanen Institute, University of Eastern Finland, tel. +358-40-3552084, email: email@example.com
The 6-year-old boy who ran over the chicken, was praised by his school for his actions after a post detailing his efforts went viral on Facebook. The viral post was shared by Facebook user Sanga Says on April 2.
“This young boy from Sairang, Mizoram, accidentally ran over his neighbour’s chicken. He took the chicken, ran to a nearby hospital and with all the money he had, asked for help,” says the post.
According to Instagram user brothalee, who shared the post wrote:
Ghana’s Vice President Dr Mahamudu Bawumia, on Wednesday, launched the first ever medical drone delivery service in Ghana, and the largest of such drone delivery network in the world, at Omenako, near Suhum, in the Eastern region.
The ‘Fly-To-Save-A-Life Project’, a collaboration between the Ministry of Health and Zipline Technologies, will provide a rapid response to medical emergencies, especially in hard to reach areas, through the flying of unmanned drones to supply 12 routine and emergency services as well as 148 lifesaving medical products selected by the Ministry of Health.
A Pastor is considering divorcing his wife and disowning his ”children” after DNA shows he is not their biological father
In his narration, the man revealed that he had an accident years ago before meeting his wife and he was told it would only take a miracle for him to father a child.
These fatty acids have many uses in the body. Naturally, people should acquire nutrients from the food that we eat. However, it may not be possible to get enough, especially if you need extra. Athletes and other people in fitness may need more to enhance their body functionalities. Kids in schools also need more to develop their brains well.
The Federal Government has rebuilt over 4000 primary healthcare centres (PHCs) across the federation in line with the10,000 rehabilitation target of the President Muhammadu Buhari administration.
The Minister of Health, Prof. Isaac Adewole, who spoke while opening the six-day medical/dental surgical mission of the Association of Nigerian Physicians in America (ANPA) for 3000 residents of Jiwa, Tungan Gwazo and Kubwa communities in Abuja, noted that the current government was reviving the collapsed primary healthcare sector and repositioning it for better delivery.
Symptomatic Pharmacotherapy should be Regularly assessed among older persons and persons with Alzheimer’s Disease
Symptomatic pharmacotherapy should be regularly assessed among older persons and persons with Alzheimer’s disease
The prevalence of using antidepressants and proton pump inhibitors increases after the diagnosis of Alzheimer’s disease, according to a doctoral dissertation from the University of Eastern Finland. The use of antidepressants was associated with an increased risk of hip fracture among persons with and without Alzheimer’s disease. The use of proton pump inhibitors, however, did not increase the risk of hip fracture even in the long term. The study also found that the concomitant use of acetylcholinesterase inhibitors and urinary antispasmodics was prevalent among persons with Alzheimer’s disease, even though the concomitant use of these drugs is not recommended due to their opposite pharmacological mechanisms.
The results are based on two Finnish nationwide datasets, MEDALZ-2005 and MEDALZ, which are combined from several health care registers. The data includes all Finnish persons who are eligible for a limited basic reimbursement for anti-dementia drugs, and their comparison persons. The concomitant use of acetylcholinesterase inhibitors and urinary antispasmodics has been rarely studied previously, and there are no previous studies of this issue among community-dwelling persons living in Finland. Moreover, the association between hip fracture and the use of antidepressants or proton pump inhibitors hasn’t been studied in Finland before, nor among persons with Alzheimer’s disease.
Antidepressant use increases hip fracture risk among elderly
Antidepressant use was associated with 60 per cent increased risk of hip fracture among persons with Alzheimer’s disease. Antidepressant use was more common among persons with Alzheimer’s disease compared to persons without, and the relative number of hip fractures was also higher. Non-pharmacological options should be preferred for the treatment of psychological and behavioural symptoms in this patient group. Antidepressants, also the newer agents, should be avoided especially among persons with several risk factors for falling and fractures.
Long-term proton pump inhibitor use is not associated with an increased risk of hip fracture
Some previous studies have suggested that long-term proton pump inhibitor use may increase the risk of hip fracture. According to this thesis, however, the risk of hip fracture is not increased even in long-term, or in cumulative use. Short-term use was slightly associated with an increased risk of hip fracture, which may be confounded by underlying factors such as other medications or diseases.
Prevalence of antidepressants and proton pump inhibitors increases strongly after Alzheimer’s disease diagnosis
The prevalence of antidepressant use doubled from three years before diagnosis (10%) compared with the time of diagnosis (20%), and was further elevated at three years after the diagnosis (29%). This finding may indicate that antidepressants are used for the treatment of psychological and behavioural symptoms of dementia. The prevalence of proton pump inhibitor use doubled from three years before the AD diagnosis (10%) to three years after the diagnosis (20%). One reason for the increased prevalence might be the treatment of gastrointestinal adverse effects of the newly initiated antidementia drugs.
Symptomatic pharmacotherapy of older persons should be regularly assessed
Due to opposite pharmacological actions, the use of urinary antispasmodics may weaken the response of anti-dementia drugs and thus, urinary antispasmodics should be avoided in persons with Alzheimer’s disease. The need for symptomatic drugs, such as antidepressants or proton pump inhibitors, should be regularly assessed among older persons and persons with Alzheimer’s disease. If there is no current need for the treatment, it should be discontinued. Changes in pharmacotherapy, however, must be discussed with a physician.
The doctoral dissertation constitutes a part of the nationwide MEDALZ (Medication use and Alzheimer’s disease) study. MEDALZ-2005 included 28,093 community-dwelling persons with limited basic reimbursement for antidementia drugs on December 31, 2005, obtained from the nationwide Special Reimbursement Register. MEDALZ included all 70,718 community-dwelling Finns who received limited basic reimbursement during 2005–2011. The study also included persons without the disease, and one to four persons without Alzheimer’s disease were matched for each person with Alzheimer’s disease based on age, sex, and region of residence. Both of the MEDALZ datasets include information from different nationwide health care register, such as information on drug purchases and diagnoses of other diseases.
The doctoral dissertation by Sanna Torvinen-Kiiskinen (MSc Pharmacy) entitled Risks associated with urinary antispasmodics, antidepressants and proton pump inhibitors – The Medication and Alzheimer’s Disease Study,is available for download at:http://epublications.uef.fi/
For further information, please contact:
Sanna Torvinen-Kiiskinen, tel. +358405021447, sanna.torvinen-kiiskinen (a) uef.fi